I created this website, with the intent to provide accurate and real-time data, that tracks the novel coronavirus. As the SARS-CoV-2 is rapidly speedily, I hope you can use this site to find up-to-date info for your location, along with current research, and recent news. This site was built using Corvid API and the real-time dashboards were built with ArcGIS, C/C++, Seaborn, Plotly, Python, HTML, and R programming languages. Get in touch if you’d like to learn more about my career and what I’m working on now.
I created this website, with the intent to provide accurate and real-time data, that tracks the novel coronavirus. As the SARS-CoV-2 is rapidly speedily, I hope you can use this site to find up-to-date info for your location, along with current research, and recent news. This site was built using Corvid API and the real-time dashboards were built with ArcGIS, C/C++, Seaborn, Plotly, Python, HTML, and R programming languages. Get in touch if you’d like to learn more about my career and what I’m working on now.
I created this website, with the intent to provide accurate and real-time data, that tracks the novel coronavirus. As the SARS-CoV-2 is rapidly speedily, I hope you can use this site to find up-to-date info for your location, along with current research, and recent news. This site was built using Corvid API and the real-time dashboards were built with ArcGIS, C/C++, Seaborn, Plotly, Python, HTML, and R programming languages. Get in touch if you’d like to learn more about my career and what I’m working on now.
S477G/N
A highly flexible region in the receptor binding domain (RBD) of SARS-CoV-2, starting from residue 475 and continuing up to residue 485, was identified using bioinformatics and statistical methods in several studies. The University of Graz and the Biotech Company Innophore have shown in a recent publication that structurally, the position S477 shows the highest flexibility among them.
At the same time, S477 is hitherto the most frequently exchanged amino acid residue in the RBDs of SARS-CoV-2 mutants. By using molecular dynamics simulations of RBD during the binding process to hACE2, it has been shown that both S477G and S477N strengthen the binding of the SARS-COV-2 spike with the hACE2 receptor. The vaccine developer BioNTech referenced this amino acid exchange as relevant regarding future vaccine design in a preprint published in February 2021.